Copper-Catalyzed Stereoselective Radical Phosphono-hydrazonation of Alkynes.
J Org Chem
; 87(21): 14555-14564, 2022 Nov 04.
Article
in En
| MEDLINE
| ID: mdl-36264682
ABSTRACT
A copper-catalyzed stereoselective phosphono-hydrazonation of terminal alkynes with alkyl carbazates and diarylphosphine oxides is described. This methodology provides facile access to a variety of ß-hydrazonophosphine oxides in satisfactory yields. The reaction proceeds under mild conditions and exhibits good functional group tolerance. A mechanism featuring persulfate-mediated oxidative generation of phosphinoyl radicals and copper-assisted hydrazonation is proposed.
Full text:
1
Database:
MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2022
Type:
Article
Affiliation country:
China