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Synthesis and characterization of carbohydrate-based biosurfactant mimetics.
Sockett, Kaitlynn A; Loffredo, Madeline; Korunes-Miller, Jenny; Varghese, Maria; Grinstaff, Mark W.
Affiliation
  • Sockett KA; Department of Chemistry, Boston University, Boston, MA, 02215, United States.
  • Loffredo M; Department of Material Science Engineering, Boston University, Boston, MA, 02215, United States.
  • Korunes-Miller J; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, United States.
  • Varghese M; Department of Chemistry, Boston University, Boston, MA, 02215, United States. Electronic address: mariavar@bu.edu.
  • Grinstaff MW; Department of Chemistry, Boston University, Boston, MA, 02215, United States; Department of Material Science Engineering, Boston University, Boston, MA, 02215, United States; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, United States. Electronic address: mgrin@bu.edu.
Carbohydr Res ; 522: 108697, 2022 Dec.
Article in En | MEDLINE | ID: mdl-36272207
ABSTRACT
Glycolipid biosurfactants are of interest for various industry sectors. We report the synthesis and characterization of enantiopure poly-amido-saccharides (PASs) containing myristoyl (C14), palmitoyl (C16), or stearoyl (C18) terminal chain lengths as mimetics of glycolipid biosurfactants. These amphiphilic polymers are water soluble, adopt a helical secondary structure, decompose at temperatures greater than 240 °C, are non-cytotoxic, and self-assemble into nanostructures. Polymers containing the shorter hydrophilic chain lengths and the hydrophobic C14 chain exhibit the lowest surface tension among all polymers.
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Full text: 1 Database: MEDLINE Main subject: Carbohydrates / Glycolipids Language: En Journal: Carbohydr Res Year: 2022 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Carbohydrates / Glycolipids Language: En Journal: Carbohydr Res Year: 2022 Type: Article Affiliation country: United States