Poor prognosis after lower-limb amputation irrespective of diabetes status in patients undergoing hemodialysis.
Ther Apher Dial
; 27(3): 495-504, 2023 Jun.
Article
in En
| MEDLINE
| ID: mdl-36331098
ABSTRACT
INTRODUCTION:
Diabetes mellitus is one of the most important risk factors for lower-limb amputation in patients undergoing hemodialysis. However, the influence of diabetes mellitus on survival after lower-limb amputation is unknown.METHODS:
Patients who underwent lower-limb amputation since 1996 (amputation group) and those who underwent hemodialysis during 2011-2012 (control group) were included and were followed up until July 2022.RESULTS:
There were 70 patients (age 66.3 ± 8.2 years, 80% male, 77% diabetic) in the amputation group and 328 (age 67.5 ± 13.5 years, 56% male, 33% diabetic) in the control group. The amputation group showed a poorer prognosis than the control group (hazard ratio [HR] 2.41, p < 0.001). In the control group, patients with diabetes exhibited poorer survival than those without diabetes (HR 1.86, p < 0.001). In the amputation group, patients with diabetes exhibited improved survival (HR 0.47, p = 0.02).CONCLUSION:
Patients undergoing hemodialysis who underwent lower-limb amputation exhibited a poor prognosis, irrespective of diabetes status.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Diabetes Mellitus
/
Peripheral Arterial Disease
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Ther Apher Dial
Journal subject:
HEMATOLOGIA
Year:
2023
Type:
Article
Affiliation country:
Japan