Galectin-3, Acute Kidney Injury and Myocardial Damage in Patients With Acute Heart Failure.
J Card Fail
; 29(3): 269-277, 2023 03.
Article
in En
| MEDLINE
| ID: mdl-36332898
ABSTRACT
BACKGROUND:
Galectin-3, a biomarker of inflammation and fibrosis, can be associated with renal and myocardial damage and dysfunction in patients with acute heart failure (AHF). METHODS ANDRESULTS:
We retrospectively analyzed 790 patients with AHF who were enrolled in the AKINESIS study. During hospitalization, patients with galectin-3 elevation (> 25.9 ng/mL) on admission more commonly had acute kidney injury (assessed by KDIGO criteria), renal tubular damage (peak urine neutrophil gelatinase-associated lipocalin [uNGAL] > 150 ng/dL) and myocardial injury (≥ 20% increase in the peak high-sensitivity cardiac troponin I [hs-cTnI] values compared to admission). They less commonly had ≥ 30% reduction in B-type natriuretic peptide from admission to last measured value. In multivariable linear regression analysis, galectin-3 was negatively associated with estimated glomerular filtration rate and positively associated with uNGAL and hs-cTnI. Higher galectin-3 was associated with renal replacement therapy, inotrope use and mortality during hospitalization. In univariable Cox regression analysis, higher galectin-3 was associated with increased risk for the composite of death or rehospitalization due to HF and death alone at 1 year. After multivariable adjustment, higher galectin-3 levels were associated only with death.CONCLUSIONS:
In patients with AHF, higher galectin-3 values were associated with renal dysfunction, renal tubular damage and myocardial injury, and they predicted worse outcomes.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Galectin 3
/
Acute Kidney Injury
/
Heart Failure
/
Cardiomyopathies
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
J Card Fail
Journal subject:
CARDIOLOGIA
Year:
2023
Type:
Article
Affiliation country:
Japan