A genomic deep field view of hypertension.
Kidney Int
; 103(1): 42-52, 2023 01.
Article
in En
| MEDLINE
| ID: mdl-36377113
ABSTRACT
Blood pressure is regulated by a complex neurohumoral system including the renin-angiotensin-aldosterone system, natriuretic peptides, endothelial pathways, the sympathetic nervous system, and the immune system. This review charts the evolution of our understanding of the genomic basis of hypertension at increasing resolution over the last 5 decades from monogenic causes to polygenic associations, spanning â¼30 monogenic rare variants and >1500 single nucleotide variants. Unexpected early wins from blood pressure genomics include deepening of our understanding of the complex causation of hypertension; refinement of causal estimates bidirectionally between blood pressure, risk factors, and outcomes through Mendelian randomization; risk stratification using polygenic risk scores; and opportunities for precision medicine and drug repurposing.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Hypertension
Type of study:
Clinical_trials
Limits:
Humans
Language:
En
Journal:
Kidney Int
Year:
2023
Type:
Article
Affiliation country:
United States