Bruton tyrosine kinase inhibitors in the management of Waldenström macroglobulinemia.
Am J Hematol
; 98(2): 338-347, 2023 02.
Article
in En
| MEDLINE
| ID: mdl-36415104
ABSTRACT
Bruton tyrosine kinase (BTK) inhibitors have taken a central role in the management of patients with Waldenström macroglobulinemia and are the only agents approved by the Food and Drug Administration (FDA) to treat these patients. Although associated with high rates of durable responses, unmet needs with BTK inhibitor therapy include indefinite duration therapy, high cost, scarcity of complete responses, and lower rates and shorter duration of response in patients with CXCR4 mutations. Herein, we review the data supporting the use of covalent BTK inhibitors, selected management issues, clinical trials with covalent BTK inhibitor combination regimens, and up-and-coming non-covalent BTK inhibitors.
Full text:
1
Database:
MEDLINE
Main subject:
Lymphoma, B-Cell
/
Waldenstrom Macroglobulinemia
Limits:
Humans
Language:
En
Journal:
Am J Hematol
Year:
2023
Type:
Article
Affiliation country:
United States