Pregnancy and post-partum in patients with myelin-oligodendrocyte glycoprotein antibody-associated disease.
Mult Scler
; 29(2): 270-276, 2023 02.
Article
in En
| MEDLINE
| ID: mdl-36453174
ABSTRACT
BACKGROUND AND OBJECTIVE:
Myelin-oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) frequently initiates during childbearing years. This study investigated the impact of pregnancy and post-partum on MOGAD activity.METHODS:
Retrospective analysis of clinical and demographic data from a multicenter French cohort of adult patients with MOGAD. All adult female patients who had a pregnancy after disease onset or in the year before disease onset were included. The annualized relapse rate was evaluated in patients who had a pregnancy after disease onset, to evaluate the impact of pregnancy and post-partum on MOGAD course.RESULTS:
Twenty-five informative pregnancies after disease onset were identified. No relapse was recorded during these pregnancies and only three relapses occurred during the first 3 months post-partum. The annualized relapse rate decreased from 0.67 (95% confidence interval 0.40-1.10) during the pre-pregnancy period to 0 (95% confidence interval 0-0.21) during pregnancy and to 0.22 (95% confidence interval 0.09-0.53) during the first year post-partum. Among 144 female patients in their childbearing age recorded in the database, 18 (12.5%) reported their first symptoms during pregnancy or in the 12 months post-partum.DISCUSSION:
Our study suggests a marked reduction of MOGAD relapse rate during pregnancy and the post-partum period. Prospective studies on the role of pregnancy and delivery in MOGAD course are needed.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Autoantibodies
/
Postpartum Period
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Mult Scler
Journal subject:
NEUROLOGIA
Year:
2023
Type:
Article
Affiliation country:
France