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Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins.
Metzger, Jeanette M; Wang, Yuyuan; Neuman, Samuel S; Snow, Kathy J; Murray, Stephen A; Lutz, Cathleen M; Bondarenko, Viktoriya; Felton, Jesi; Gimse, Kirstan; Xie, Ruosen; Li, Dongdong; Zhao, Yi; Flowers, Matthew T; Simmons, Heather A; Roy, Subhojit; Saha, Krishanu; Levine, Jon E; Emborg, Marina E; Gong, Shaoqin.
Affiliation
  • Metzger JM; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Wang Y; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53715, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Neuman SS; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Snow KJ; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
  • Murray SA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
  • Lutz CM; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
  • Bondarenko V; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Felton J; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Gimse K; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53715, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Xie R; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53715, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Li D; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53715, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Zhao Y; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53715, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Flowers MT; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Simmons HA; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Roy S; Departments of Pathology and Neuroscience, University of California-San Diego, San Diego, CA, 92093, USA.
  • Saha K; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53715, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Levine JE; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, 53715, USA.
  • Emborg ME; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, 53715, USA. Electronic address: emborg@wisc.edu.
  • Gong S; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53715, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA. Elec
Biomaterials ; 293: 121959, 2023 Feb.
Article in En | MEDLINE | ID: mdl-36527789
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Full text: 1 Database: MEDLINE Main subject: Nanocapsules / Gene Editing Limits: Animals Language: En Journal: Biomaterials Year: 2023 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Nanocapsules / Gene Editing Limits: Animals Language: En Journal: Biomaterials Year: 2023 Type: Article Affiliation country: United States