Predictors of Intensive Care Admission in Hypoxemic Bronchiolitis Infants, Secondary Analysis of a Randomized Trial.
J Pediatr
; 256: 92-97.e1, 2023 05.
Article
in En
| MEDLINE
| ID: mdl-36528052
ABSTRACT
OBJECTIVES:
To evaluate in a preplanned secondary analysis of our parent randomized controlled trial predictors of intensive care unit (ICU) admission in infants with bronchiolitis and analyze if these predictors are equally robust for children receiving high-flow or standard-oxygen. STUDYDESIGN:
A secondary analysis of a multicenter, randomized trial of infants aged <12 months with bronchiolitis and an oxygen requirement was performed using admission and outcome data of all 1472 enrolled infants. The primary outcome was ICU admission. The predictors evaluated were baseline characteristics including physiological data and medical history.RESULTS:
Of the 1472 enrolled infants, 146 were admitted to intensive care. Multivariate predictors of ICU admission were age (weeks) (OR 0.98 [95% CI 0.96-0.99]), pre-enrolment heart rate >160/min (OR 1.80 [95% CI 1.23-2.63]), pre-enrolment SpO2 (transcutaneous oxygen saturation) (%) (OR 0.91 [95% CI 0.86-0.95]), previous ICU admission (OR 2.16 [95% CI 1.07-4.40]), and time of onset of illness to hospital presentation (OR 0.78 [95% CI 0.65-0.94]). The predictors were equally robust for infants on high-flow nasal cannula therapy or standard-oxygen therapy.CONCLUSION:
Age <2 months, pre-enrolment heart rate >160/min, pre-enrolment SpO2 of <87%, previous ICU admission and time of onset of ≤2 days to presentation are predictive of an ICU admission during the current hospital admission of infants with bronchiolitis independent of oxygenation method used. TRIAL REGISTRATION ACTRN12613000388718.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Bronchiolitis
/
Hospitalization
Type of study:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Humans
/
Infant
Language:
En
Journal:
J Pediatr
Year:
2023
Type:
Article