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Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
Slavish, Peter J; Cuypers, Maxime G; Rimmer, Mary Ashley; Abdolvahabi, Alireza; Jeevan, Trushar; Kumar, Gyanendra; Jarusiewicz, Jamie A; Vaithiyalingam, Sivaraja; Jones, Jeremy C; Bowling, John J; Price, Jeanine E; DuBois, Rebecca M; Min, Jaeki; Webby, Richard J; Rankovic, Zoran; White, Stephen W.
Affiliation
  • Slavish PJ; Departments of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Cuypers MG; Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Rimmer MA; Departments of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Abdolvahabi A; Departments of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Jeevan T; Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Kumar G; Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Jarusiewicz JA; Departments of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Vaithiyalingam S; Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Jones JC; Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Bowling JJ; Departments of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Price JE; Departments of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • DuBois RM; Baskin School of Engineering, University of California at Santa Cruz, Santa Cruz, CA, 95064, USA.
  • Min J; Departments of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Webby RJ; Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Rankovic Z; Departments of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. Electronic address: zoran.rankovic@stjude.org.
  • White SW; Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. Electronic address: stevew.white@stjude.org.
Eur J Med Chem ; 247: 115035, 2023 Feb 05.
Article in En | MEDLINE | ID: mdl-36603507
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Full text: 1 Database: MEDLINE Main subject: Orthomyxoviridae / HIV Integrase Inhibitors / Dibenzothiepins / Influenza, Human Limits: Humans Language: En Journal: Eur J Med Chem Year: 2023 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Orthomyxoviridae / HIV Integrase Inhibitors / Dibenzothiepins / Influenza, Human Limits: Humans Language: En Journal: Eur J Med Chem Year: 2023 Type: Article Affiliation country: United States