DEHP mediates drug resistance by metabolic reprogramming in colorectal cancer cells.
Environ Sci Pollut Res Int
; 30(16): 47780-47786, 2023 Apr.
Article
in En
| MEDLINE
| ID: mdl-36749513
ABSTRACT
Long-term exposure to diethylhexyl phthalate (DEHP), an endocrine-disrupting chemical (EDCs) and plasticizer widely used in consumer products, has been reported to be significantly positively correlated with increased risks of different human diseases, including various cancers, while the potential effect of DEHP on colorectal cancer progression was little studied. In the present study, we showed that DEHP could trigger the metabolic reprogramming of colorectal cancer cells, promote cell growth and decrease fluorouracil (5-FU) sensitivity. Mechanistic studies indicated that DEHP could reduce glycolysis activity and increase oxidative phosphorylation (OXPHOS) in SW620 cells. In addition, in vivo experiments showed that DEHP promoted tumorigenic progression and decreased survival time in mice. Collectively, our findings suggest that DEHP may be a potent risk factor for colorectal cancer development.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Insulin Resistance
/
Colorectal Neoplasms
/
Diethylhexyl Phthalate
Type of study:
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Environ Sci Pollut Res Int
Journal subject:
SAUDE AMBIENTAL
/
TOXICOLOGIA
Year:
2023
Type:
Article
Affiliation country:
China