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Management of Recurrent Well-Differentiated Thyroid Carcinoma in the Neck: A Comprehensive Review.
Cavalheiro, Beatriz G; Shah, Jatin P; Randolph, Gregory W; Medina, Jesus E; Tufano, Ralph P; Zafereo, Mark; Hartl, Dana M; Nixon, Iain J; Guntinas-Lichius, Orlando; Vander Poorten, Vincent; López, Fernando; Khafif, Avi Hefetz; Owen, Randall P; Shaha, Ashok; Rodrigo, Juan P; Rinaldo, Alessandra; Mäkitie, Antti A; Silver, Carl E; Sanabria, Alvaro; Kowalski, Luiz P; Ferlito, Alfio.
Affiliation
  • Cavalheiro BG; Cancer Institute of São Paulo State, Department of Head and Neck Surgery, University of São Paulo Medical School, Sao Paulo 01246-903, Brazil.
  • Shah JP; Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Randolph GW; Department of Otolaryngology Head and Neck Surgery, Harvard Medical School, Boston, MA 02115, USA.
  • Medina JE; Department of Otolaryngology and Head and Neck Surgery, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA.
  • Tufano RP; Multidisciplinary Thyroid and Parathyroid Center, Head and Neck Endocrine Surgery, Sarasota Memorial Health Care System, Sarasota, FL 34239, USA.
  • Zafereo M; Department of Head & Neck Surgery, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Hartl DM; Department of Surgery, Gustave Roussy, 94800 Villejuif, France.
  • Nixon IJ; Department of Otolaryngology Head and Neck Surgery, NHS Lothian, University of Edinburgh, Edinburgh EH8 9YL, UK.
  • Guntinas-Lichius O; Department of Otorhinolaryngology-Head and Neck Surgery, Jena University Hospital, 07747 Jena, Germany.
  • Vander Poorten V; Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, 3000 Leuven, Belgium.
  • López F; ENT and Head and Neck Department, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, 33011 Oviedo, Spain.
  • Khafif AH; Centro de Investigación Biomédica en Red de Cancer (CIBERONC), 28029 Madrid, Spain.
  • Owen RP; Assuta Medical Center, Ben-Gurion University of the Negev, Tel Aviv 8436322, Israel.
  • Shaha A; Section of Endocrine Surgery, Division of Surgical Oncology, Department of Surgery, Mount Sinai Hospital, Icahn School of Medicine, New York, NY 10029, USA.
  • Rodrigo JP; Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  • Rinaldo A; ENT and Head and Neck Department, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, 33011 Oviedo, Spain.
  • Mäkitie AA; Centro de Investigación Biomédica en Red de Cancer (CIBERONC), 28029 Madrid, Spain.
  • Silver CE; School of Medicine, University of Udine, 33100 Udine, Italy.
  • Sanabria A; Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, 00290 Helsinki, Finland.
  • Kowalski LP; Department of Surgery, University of Arizona College of Medicine, Phoenix, AZ 85724, USA.
  • Ferlito A; Department of Surgery, School of Medicine, University of Antioquia, Medellín 0500100, Colombia.
Cancers (Basel) ; 15(3)2023 Feb 01.
Article in En | MEDLINE | ID: mdl-36765880
Surgery has been historically the preferred primary treatment for patients with well-differentiated thyroid carcinoma and for selected locoregional recurrences. Adjuvant therapy with radioactive iodine is typically recommended for patients with an intermediate to high risk of recurrence. Despite these treatments, locally advanced disease and locoregional relapses are not infrequent. These patients have a prolonged overall survival that may result in long periods of active disease and the possibility of requiring subsequent treatments. Recently, many new options have emerged as salvage therapies. This review offers a comprehensive discussion and considerations regarding surgery, active surveillance, radioactive iodine therapy, ultrasonography-guided percutaneous ablation, external beam radiotherapy, and systemic therapy for well-differentiated thyroid cancer based on relevant publications and current reference guidelines. We feel that the surgical member of the thyroid cancer management team is empowered by being aware and facile with all management options.
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Full text: 1 Database: MEDLINE Type of study: Guideline / Qualitative_research Language: En Journal: Cancers (Basel) Year: 2023 Type: Article Affiliation country: Brazil
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Full text: 1 Database: MEDLINE Type of study: Guideline / Qualitative_research Language: En Journal: Cancers (Basel) Year: 2023 Type: Article Affiliation country: Brazil