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Rapid and Highly Productive Assembly of a Disulfide Bond in Solid-Phase Peptide Macrocyclization.
Chowdhury, Arnab; Gour, Vinod; Das, Basab Kanti; Chatterjee, Saurav; Bandyopadhyay, Anupam.
Affiliation
  • Chowdhury A; Biomimetic Peptide Engineering Lab, Department of Chemistry, Indian Institute of Technology Ropar, Baraphool, Rupnagar, Punjab, India 140001.
  • Gour V; Biomimetic Peptide Engineering Lab, Department of Chemistry, Indian Institute of Technology Ropar, Baraphool, Rupnagar, Punjab, India 140001.
  • Das BK; Biomimetic Peptide Engineering Lab, Department of Chemistry, Indian Institute of Technology Ropar, Baraphool, Rupnagar, Punjab, India 140001.
  • Chatterjee S; Biomimetic Peptide Engineering Lab, Department of Chemistry, Indian Institute of Technology Ropar, Baraphool, Rupnagar, Punjab, India 140001.
  • Bandyopadhyay A; Biomimetic Peptide Engineering Lab, Department of Chemistry, Indian Institute of Technology Ropar, Baraphool, Rupnagar, Punjab, India 140001.
Org Lett ; 25(8): 1280-1284, 2023 03 03.
Article in En | MEDLINE | ID: mdl-36800531
ABSTRACT
Here we report a highly efficient disulfide-driven peptide macrocyclization in 15 min on a solid support using persulfate as a crucial additive in iodine-mediated oxidative cyclization. The method eliminates the side products of classical iodine-mediated peptide cyclization. It is operationally simple and convenient for cyclizing small to lengthier peptides embodying popular cysteine building blocks in a single step.
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Full text: 1 Database: MEDLINE Main subject: Peptides / Cysteine Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2023 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Peptides / Cysteine Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2023 Type: Article