A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1.

Numata, Masashi; Haginoya, Noriyasu; Shiroishi, Machiko; Hirata, Tsuyoshi; Sato-Otsubo, Aiko; Yoshikawa, Kenji; Takata, Yoshimi; Nagase, Reina; Kashimoto, Yoshinori; Suzuki, Makoto; Schulte, Nina; Polier, Gernot; Kurimoto, Akiko; Tomoe, Yumiko; Toyota, Akiko; Yoneyama, Tomoko; Imai, Emi; Watanabe, Kenji; Hamada, Tomoaki; Kanada, Ryutaro; Watanabe, Jun; Kagoshima, Yoshiko; Tokumaru, Eri; Murata, Kenji; Baba, Takayuki; Shinozaki, Taeko; Ohtsuka, Masami; Goto, Koichi; Karibe, Tsuyoshi; Deguchi, Takao; Gocho, Yoshihiro; Yoshida, Masanori; Tomizawa, Daisuke; Kato, Motohiro; Tsutsumi, Shinji; Kitagawa, Mayumi; Abe, Yuki

Numata, Masashi; Haginoya, Noriyasu; Shiroishi, Machiko; Hirata, Tsuyoshi; Sato-Otsubo, Aiko; Yoshikawa, Kenji; Takata, Yoshimi; Nagase, Reina; Kashimoto, Yoshinori; Suzuki, Makoto; Schulte, Nina; Polier, Gernot; Kurimoto, Akiko; Tomoe, Yumiko; Toyota, Akiko; Yoneyama, Tomoko; Imai, Emi; Watanabe, Kenji; Hamada, Tomoaki; Kanada, Ryutaro; Watanabe, Jun; Kagoshima, Yoshiko; Tokumaru, Eri; Murata, Kenji; Baba, Takayuki; Shinozaki, Taeko; Ohtsuka, Masami; Goto, Koichi; Karibe, Tsuyoshi; Deguchi, Takao; Gocho, Yoshihiro; Yoshida, Masanori; Tomizawa, Daisuke; Kato, Motohiro; Tsutsumi, Shinji; Kitagawa, Mayumi; Abe, Yuki.

Affiliation

Numata M; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Haginoya N; Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan.
Shiroishi M; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Hirata T; Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan.
Sato-Otsubo A; Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
Yoshikawa K; Department of Pediatrics, University of Tokyo, Tokyo, Japan.
Takata Y; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Nagase R; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Kashimoto Y; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Suzuki M; Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan.
Schulte N; Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan.
Polier G; Daiichi Sankyo Europe GmbH, Munich, Germany.
Kurimoto A; Daiichi Sankyo Europe GmbH, Munich, Germany.
Tomoe Y; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Toyota A; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Yoneyama T; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Imai E; Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan.
Watanabe K; Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan.
Hamada T; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Kanada R; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Watanabe J; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Kagoshima Y; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Tokumaru E; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Murata K; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Baba T; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Shinozaki T; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Ohtsuka M; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Goto K; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Karibe T; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Deguchi T; Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan.
Gocho Y; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Yoshida M; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Tomizawa D; Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
Kato M; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Tsutsumi S; Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
Kitagawa M; Department of Pediatrics, University of Tokyo, Tokyo, Japan.
Abe Y; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.