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Efficacy and safety of garadacimab, a factor XIIa inhibitor for hereditary angioedema prevention (VANGUARD): a global, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
Craig, Timothy J; Reshef, Avner; Li, H Henry; Jacobs, Joshua S; Bernstein, Jonathan A; Farkas, Henriette; Yang, William H; Stroes, Erik S G; Ohsawa, Isao; Tachdjian, Raffi; Manning, Michael E; Lumry, William R; Saguer, Inmaculada Martinez; Aygören-Pürsün, Emel; Ritchie, Bruce; Sussman, Gordon L; Anderson, John; Kawahata, Kimito; Suzuki, Yusuke; Staubach, Petra; Treudler, Regina; Feuersenger, Henrike; Glassman, Fiona; Jacobs, Iris; Magerl, Markus.
Affiliation
  • Craig TJ; Allergy, Asthma and Immunology, Department of Medicine and Pediatrics, Penn State University, Hershey, PA, USA. Electronic address: tcraig@pennstatehealth.psu.edu.
  • Reshef A; Allergy, Immunology & Angioedema Center, Barzilai University Hospital, Ashkelon, Israel.
  • Li HH; Institute for Asthma and Allergy, Chevy Chase, MD, USA.
  • Jacobs JS; Allergy & Asthma Clinical Research, Walnut Creek, CA, USA.
  • Bernstein JA; University of Cincinnati, Department of Internal Medicine Division of Rheumatology, Allergy and Immunology and the Bernstein Clinical Research Center Cincinnati, Cincinnati, OH, USA.
  • Farkas H; Department of Internal Medicine and Haematology, Hungarian Angioedema Center of Reference and Excellence, Semmelweis University, Budapest, Hungary.
  • Yang WH; Ottawa Allergy Research Corporation, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
  • Stroes ESG; Department of Vascular Medicine, Amsterdam UMC, Amsterdam, Netherlands.
  • Ohsawa I; Department of Nephrology, Saiyu Soka Hospital, Saitama, Japan.
  • Tachdjian R; Division of Allergy & Clinical Immunology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
  • Manning ME; Allergy, Asthma & Immunology Associates, Ltd, Internal Medicine, UA College of Medicine, Phoenix, Phoenix, AZ, USA.
  • Lumry WR; AARA Research Center, Dallas, TX, USA.
  • Saguer IM; HZRM Haemophilia Center Rhein Main, Mörfelden-Walldorf, Germany.
  • Aygören-Pürsün E; Klinikum der Johann Wolfgang-Goethe Universität, Klinik für Kinder- und Jugendmedizin, Frankfurt, Germany.
  • Ritchie B; Division of Hematology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
  • Sussman GL; Gordon Sussman Clinical Research Inc and Department of Clinical Immunology and Allergy, St Michael's Hospital, Toronto, ON, Canada.
  • Anderson J; AllerVie Clinical Research, Birmingham, AL, USA.
  • Kawahata K; St Marianna University School of Medicine, Kawasaki-shi, Kanagawa, Japan.
  • Suzuki Y; Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.
  • Staubach P; Department of Dermatology and Allergy, University Medical Center, Mainz, Germany.
  • Treudler R; University Leipzig Medical Faculty, Department of Dermatology, Venereology and Allergology, Leipzig Interdisciplinary Center for Allergology-CAC, Leipzig, Germany.
  • Feuersenger H; CSL Behring Innovation GmbH, Marburg, Germany.
  • Glassman F; CSL Behring, King of Prussia, PA, USA.
  • Jacobs I; CSL Behring, King of Prussia, PA, USA.
  • Magerl M; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Frauhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.
Lancet ; 401(10382): 1079-1090, 2023 04 01.
Article in En | MEDLINE | ID: mdl-36868261
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Full text: 1 Database: MEDLINE Main subject: Angioedemas, Hereditary Type of study: Clinical_trials Limits: Adolescent / Adult / Female / Humans / Male Language: En Journal: Lancet Year: 2023 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Angioedemas, Hereditary Type of study: Clinical_trials Limits: Adolescent / Adult / Female / Humans / Male Language: En Journal: Lancet Year: 2023 Type: Article