Non-sugar sweeteners and cancer: Toxicological and epidemiological evidence.
Regul Toxicol Pharmacol
; 139: 105369, 2023 Mar.
Article
in En
| MEDLINE
| ID: mdl-36870410
ABSTRACT
Several toxicological and epidemiological studies were published during the last five decades on non-sugar sweeteners (NSS) and cancer. Despite the large amount of research, the issue still continues to be of interest. In this review, we provided a comprehensive quantitative review of the toxicological and epidemiological evidence on the possible relation between NSS and cancer. The toxicological section includes the evaluation of genotoxicity and carcinogenicity data for acesulfame K, advantame, aspartame, cyclamates, saccharin, steviol glycosides and sucralose. The epidemiological section includes the results of a systematic search of cohort and case-control studies. The majority of the 22 cohort studies and 46 case-control studies showed no associations. Some risks for bladder, pancreas and hematopoietic cancers found in a few studies were not confirmed in other studies. Based on the review of both the experimental data on genotoxicity or carcinogenicity of the specific NSS evaluated, and the epidemiological studies it can be concluded that there is no evidence of cancer risk associated to NSS consumption.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Sweetening Agents
/
Neoplasms
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Regul Toxicol Pharmacol
Year:
2023
Type:
Article
Affiliation country:
Italy