Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.
Nucleic Acids Res
; 51(11): 5301-5324, 2023 06 23.
Article
in En
| MEDLINE
| ID: mdl-36882085
Ribosomes are macromolecular machines responsible for protein synthesis in all living beings. Recent studies have shown that ribosomes can be heterogeneous in their structure, possibly leading to a specialized function. Here, we focus on RPL3L, a ribosomal protein expressed exclusively in striated muscles. We find that the deletion of the Rpl3l gene in a mouse model triggers a compensation mechanism, in which the missing RPL3L protein is replaced by its paralogue, RPL3. Furthermore, we find that RPL3-containing ribosomes establish closer interactions with mitochondria, cellular organelles responsible for energy production, leading to higher energy production when compared with RPL3L-containing ribosomes. Finally, we show that the RPL3RPL3L compensation mechanism is also triggered in heart disease conditions, such as hypertrophy and myocardial infarction.
Full text:
1
Database:
MEDLINE
Main subject:
Ribosomal Proteins
/
Ribosomes
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Heart
/
Mitochondria
Limits:
Animals
Language:
En
Journal:
Nucleic Acids Res
Year:
2023
Type:
Article
Affiliation country:
Spain