Clinicoserological insights into patients with immune checkpoint inhibitor-induced myasthenia gravis.
Ann Clin Transl Neurol
; 10(5): 825-831, 2023 05.
Article
in En
| MEDLINE
| ID: mdl-36924454
ABSTRACT
To compare the immunopathology of immune checkpoint inhibitor-induced myasthenia gravis (ICI-MG) and idiopathic MG, we profiled the respective AChR autoantibody pathogenic properties. Of three ICI-MG patients with AChR autoantibodies, only one showed complement activation and modulation/blocking potency, resembling idiopathic MG. In contrast, AChR autoantibody-mediated effector functions were not detected in the other two patients, questioning the role of their AChR autoantibodies as key mediators of pathology. The contrasting properties of AChR autoantibodies in these cases challenge the accuracy of serological testing in establishing definite ICI-MG diagnoses and underscore the importance of a thorough clinical assessment when evaluating ICI-related adverse events.
Full text:
1
Database:
MEDLINE
Main subject:
Immune Checkpoint Inhibitors
/
Myasthenia Gravis
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Ann Clin Transl Neurol
Year:
2023
Type:
Article
Affiliation country:
United States