Investigating New Applications of a Photoswitchable Fluorescent Norbornadiene as a Multifunctional Probe for Delineation of Amyloid Plaque Polymorphism.

Dreos, Ambra; Ge, Junyue; Najera, Francisco; Tebikachew, Behabitu Ergette; Perez-Inestrosa, Ezequiel; Moth-Poulsen, Kasper; Blennow, Kaj; Zetterberg, Henrik; Hanrieder, Jörg

Dreos, Ambra; Ge, Junyue; Najera, Francisco; Tebikachew, Behabitu Ergette; Perez-Inestrosa, Ezequiel; Moth-Poulsen, Kasper; Blennow, Kaj; Zetterberg, Henrik; Hanrieder, Jörg.

Affiliation

Dreos A; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, 43180 Mölndal, Sweden.
Ge J; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma Bionand, 29590 Malaga, Spain.
Najera F; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, 43180 Mölndal, Sweden.
Tebikachew BE; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma Bionand, 29590 Malaga, Spain.
Perez-Inestrosa E; Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain.
Moth-Poulsen K; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 41296 Gothenburg, Sweden.
Blennow K; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma Bionand, 29590 Malaga, Spain.
Zetterberg H; Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain.
Hanrieder J; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 41296 Gothenburg, Sweden.

ACS Sens ; 8(4): 1500-1509, 2023 04 28.

Article in En | MEDLINE | ID: mdl-36946692

Subject(s)

Alzheimer Disease; Amyloid beta-Peptides; Mice; Animals; Amyloid beta-Peptides/chemistry; Plaque, Amyloid/pathology; Disease Models, Animal; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods; Alzheimer Disease/diagnostic imaging; Alzheimer Disease/pathology; Mice, Transgenic; Fluorescent Dyes

Key words

Alzheimer's disease (AD); amyloid beta (Aß); amyloid polymorphism; fluorescence imaging; multifunctional probes; norbornadiene (NBD); photoswitches

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Full text: 1 Database: MEDLINE Main subject: Amyloid beta-Peptides / Alzheimer Disease Type of study: Prognostic_studies Limits: Animals Language: En Journal: ACS Sens Year: 2023 Type: Article Affiliation country: Sweden

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