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Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies.
Vauleon, Stephanie; Schutz, Katharina; Massonnet, Benoit; Gruben, Nanda; Manchester, Marianne; Buehler, Alessandra; Schick, Eginhard; Boak, Lauren; Hawellek, David J.
Affiliation
  • Vauleon S; Regulated Bioanalysis, Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Schutz K; Regulated Bioanalysis, Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Massonnet B; Regulated Bioanalysis, Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Gruben N; ICON Bioanalytical Laboratories, Assen, The Netherlands.
  • Manchester M; Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Buehler A; Regulated Bioanalysis, Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Schick E; Regulated Bioanalysis, Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Boak L; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Hawellek DJ; Biomarkers and Translational Technologies, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland. david.hawellek@roche.com.
Sci Rep ; 13(1): 5332, 2023 04 01.
Article in En | MEDLINE | ID: mdl-37005488
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Full text: 1 Database: MEDLINE Main subject: Huntington Disease Limits: Humans Language: En Journal: Sci Rep Year: 2023 Type: Article Affiliation country: Switzerland
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Full text: 1 Database: MEDLINE Main subject: Huntington Disease Limits: Humans Language: En Journal: Sci Rep Year: 2023 Type: Article Affiliation country: Switzerland