Quinolizidine alkaloids in lupine flour and lupine products from the German retail market and risk assessment of the results regarding human health.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
; 40(5): 667-674, 2023 May.
Article
in En
| MEDLINE
| ID: mdl-37011027
ABSTRACT
This study describes the analysis of five quinolizidine alkaloids (QA), i.e. 13-OH-lupanine, lupanine, lupinine, angustifoline and sparteine in 30 samples of lupine flours, lupine seeds and derived products collected 2019-2021 on the German retail market. QA occur as secondary metabolites in plants of lupine species. Certain QA are of toxicological relevance. The analytical determination performed by LC-MS/MS revealed some samples with high QA concentrations (up to 21,000 mg/kg), particularly in bitter lupine seeds. As those concentrations would result in substantial exceedances of the maximum tolerable intake values proposed by health authorities, they must be considered as a health concern.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Lupinus
/
Alkaloids
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
Journal subject:
CIENCIAS DA NUTRICAO
Year:
2023
Type:
Article
Affiliation country:
Germany