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ß-secretase 1 overexpression by AAV-mediated gene delivery prevents retina degeneration in a mouse model of age-related macular degeneration.
Qi, Xiaoping; Francelin, Carolina; Mitter, Sayak; Boye, Sanford L; Gu, Hongmei; Quigley, Judith; Grant, Maria B; Boulton, Michael E.
Affiliation
  • Qi X; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Francelin C; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Mitter S; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Boye SL; MD-Powell Gene Therapy Center, University of Florida, Gainesville, FL 32611, USA.
  • Gu H; Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Quigley J; Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Grant MB; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Boulton ME; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: meboulton@uabmc.edu.
Mol Ther ; 31(7): 2042-2055, 2023 07 05.
Article in En | MEDLINE | ID: mdl-37016576
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Full text: 1 Database: MEDLINE Main subject: Amyloid Precursor Protein Secretases / Macular Degeneration Limits: Animals Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2023 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Amyloid Precursor Protein Secretases / Macular Degeneration Limits: Animals Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2023 Type: Article Affiliation country: United States