Extracellular vesicle-mediated remodeling of the bone marrow microenvironment in myeloid malignancies.
Int J Hematol
; 117(6): 821-829, 2023 Jun.
Article
in En
| MEDLINE
| ID: mdl-37041345
ABSTRACT
Hematopoiesis is maintained and regulated by a bone marrow-specific microenvironment called a niche. In hematological malignancies, tumor cells induce niche remodeling, and the reconstructed niche is closely linked to disease pathogenesis. Recent studies have suggested that extracellular vesicles (EVs) secreted from tumor cells play a principal role in niche remodeling in hematological malignancies. Although EVs are emerging as potential therapeutic targets, the underlying mechanism of action remains unclear, and selective inhibition remains a challenge. This review summarizes remodeling of the bone marrow microenvironment in hematological malignancies and its contribution to pathogenesis, as well as roles of tumor-derived EVs, and provides a perspective on future research in this field.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Hematologic Neoplasms
/
Extracellular Vesicles
/
Myeloproliferative Disorders
Limits:
Humans
Language:
En
Journal:
Int J Hematol
Journal subject:
HEMATOLOGIA
Year:
2023
Type:
Article
Affiliation country:
Japan