Spiroligomer-Based Macrocycles for Atomically Precise Membranes.
Angew Chem Int Ed Engl
; 62(27): e202302809, 2023 Jul 03.
Article
in En
| MEDLINE
| ID: mdl-37075196
ABSTRACT
Here, we report a new class of peptidomimetic macrocycles with well-defined three-dimensional structures and low conformational flexibility. They are assembled from fused-ring spiro-ladder oligomers (spiroligomers) by modular solid-phase synthesis. Two-dimensional nuclear magnetic resonance confirms their shape persistency. Triangular macrocycles of tunable sizes assemble into membranes with atomically precise pores, which exhibit size and shape-dependent molecular sieving towards a series of structurally similar compounds. The exceptional structural diversity and stability of spiroligomer-based macrocycles will be explored for more applications.
Full text:
1
Database:
MEDLINE
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2023
Type:
Article
Affiliation country:
United States