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Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer.
Wang, Mengdie; Wisniewski, Christi A; Xiong, Choua; Chhoy, Peter; Goel, Hira Lal; Kumar, Ayush; Zhu, Lihua Julie; Li, Rui; St Louis, Pamela A; Ferreira, Lindsay M; Pakula, Hubert; Xu, Zhiwen; Loda, Massimo; Jiang, Zhong; Brehm, Michael A; Mercurio, Arthur M.
Affiliation
  • Wang M; Departments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan School of Medicine, Worcester, MA 01605, USA.
  • Wisniewski CA; Departments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan School of Medicine, Worcester, MA 01605, USA.
  • Xiong C; Departments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan School of Medicine, Worcester, MA 01605, USA.
  • Chhoy P; Departments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan School of Medicine, Worcester, MA 01605, USA.
  • Goel HL; Departments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan School of Medicine, Worcester, MA 01605, USA.
  • Kumar A; Departments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan School of Medicine, Worcester, MA 01605, USA.
  • Zhu LJ; Program in Molecular Medicine, University of Massachusetts Chan School of Medicine, Worcester, MA 01605, USA.
  • Li R; Program in Molecular Medicine, University of Massachusetts Chan School of Medicine, Worcester, MA 01605, USA.
  • St Louis PA; Department of Neurology, University of Massachusetts Chan School of Medicine, Worcester, MA 01605, USA.
  • Ferreira LM; Program in Molecular Medicine, University of Massachusetts Chan School of Medicine, Worcester, MA 01605, USA.
  • Pakula H; Department of Pathology, Cornell Weill School of Medicine, New York, NY 10065, USA.
  • Xu Z; aTyr Pharma Inc., San Diego CA, 92121, USA.
  • Loda M; Department of Pathology, Cornell Weill School of Medicine, New York, NY 10065, USA.
  • Jiang Z; Department of Oncologic Pathology, Dana-Farber Cancer Institute (DFCI) and Harvard Medical School, Boston, MA 02215, USA.
  • Brehm MA; Department of Pathology, University of Massachusetts Chan School of Medicine, Worcester, MA 01605, USA.
  • Mercurio AM; Program in Molecular Medicine, University of Massachusetts Chan School of Medicine, Worcester, MA 01605, USA.
Sci Transl Med ; 15(694): eade5855, 2023 05 03.
Article in En | MEDLINE | ID: mdl-37134151
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Full text: 1 Database: MEDLINE Main subject: Prostatic Neoplasms / Vascular Endothelial Growth Factor A Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2023 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Prostatic Neoplasms / Vascular Endothelial Growth Factor A Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2023 Type: Article Affiliation country: United States