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Dual targeted 2-Benzylideneindanone pendant hydroxamic acid group exhibits selective HDAC6 inhibition along with tubulin stabilization effect.
Kumar, Kapil; Das, Ranjana; Thapa, Barsha; Rakhecha, Bharti; Srivastava, Sapna; Savita, Kumari; Israr, Monazza; Chanda, Debabrata; Banerjee, Dibyendu; Shanker, Karuna; Bawankule, D U; Santini, Benedetta; Di Paolo, Maria Luisa; Via, Lisa Dalla; Passarella, Daniele; Negi, Arvind Singh.
Affiliation
  • Kumar K; CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India.
  • Das R; CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India.
  • Thapa B; CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India.
  • Rakhecha B; CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
  • Srivastava S; CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
  • Savita K; CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India.
  • Israr M; CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India.
  • Chanda D; CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India; Academy of Science and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India.
  • Banerjee D; CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India; Academy of Science and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India.
  • Shanker K; CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India; Academy of Science and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India.
  • Bawankule DU; CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India; Academy of Science and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India.
  • Santini B; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.
  • Di Paolo ML; Department of Molecular Medicine, University of Padova, via G. Colombo 3, 35131 Padova, Italy.
  • Via LD; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via F. Marzolo 5, 35131 Padova, Italy.
  • Passarella D; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.
  • Negi AS; CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India; Academy of Science and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India. Electronic address: as.negi@cimap.res.in.
Bioorg Med Chem ; 86: 117300, 2023 05 15.
Article in En | MEDLINE | ID: mdl-37146520
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Full text: 1 Database: MEDLINE Main subject: Tubulin / Antineoplastic Agents Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2023 Type: Article Affiliation country: India
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Full text: 1 Database: MEDLINE Main subject: Tubulin / Antineoplastic Agents Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2023 Type: Article Affiliation country: India