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Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer.
Rojas, Luis A; Sethna, Zachary; Soares, Kevin C; Olcese, Cristina; Pang, Nan; Patterson, Erin; Lihm, Jayon; Ceglia, Nicholas; Guasp, Pablo; Chu, Alexander; Yu, Rebecca; Chandra, Adrienne Kaya; Waters, Theresa; Ruan, Jennifer; Amisaki, Masataka; Zebboudj, Abderezak; Odgerel, Zagaa; Payne, George; Derhovanessian, Evelyna; Müller, Felicitas; Rhee, Ina; Yadav, Mahesh; Dobrin, Anton; Sadelain, Michel; Luksza, Marta; Cohen, Noah; Tang, Laura; Basturk, Olca; Gönen, Mithat; Katz, Seth; Do, Richard Kinh; Epstein, Andrew S; Momtaz, Parisa; Park, Wungki; Sugarman, Ryan; Varghese, Anna M; Won, Elizabeth; Desai, Avni; Wei, Alice C; D'Angelica, Michael I; Kingham, T Peter; Mellman, Ira; Merghoub, Taha; Wolchok, Jedd D; Sahin, Ugur; Türeci, Özlem; Greenbaum, Benjamin D; Jarnagin, William R; Drebin, Jeffrey; O'Reilly, Eileen M.
Affiliation
  • Rojas LA; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Sethna Z; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Soares KC; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Olcese C; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Pang N; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Patterson E; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Lihm J; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Ceglia N; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Guasp P; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Chu A; Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Yu R; Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Chandra AK; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Waters T; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Ruan J; Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Amisaki M; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Zebboudj A; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Odgerel Z; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Payne G; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Derhovanessian E; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Müller F; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Rhee I; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Yadav M; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Dobrin A; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Sadelain M; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Luksza M; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Cohen N; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Tang L; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Basturk O; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Gönen M; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Katz S; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Do RK; BioNTech, Mainz, Germany.
  • Epstein AS; BioNTech, Mainz, Germany.
  • Momtaz P; Genentech, San Francisco, CA, USA.
  • Park W; Genentech, San Francisco, CA, USA.
  • Sugarman R; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Varghese AM; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Won E; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Desai A; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Wei AC; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • D'Angelica MI; Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Kingham TP; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Mellman I; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Merghoub T; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Wolchok JD; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Sahin U; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Türeci Ö; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Greenbaum BD; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Jarnagin WR; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Drebin J; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • O'Reilly EM; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nature ; 618(7963): 144-150, 2023 Jun.
Article in En | MEDLINE | ID: mdl-37165196
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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Lymphocyte Activation / T-Lymphocytes / Cancer Vaccines / Carcinoma, Pancreatic Ductal / Antigens, Neoplasm Limits: Humans Language: En Journal: Nature Year: 2023 Type: Article Affiliation country: United States
Fulltext
Add to My VHL
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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Lymphocyte Activation / T-Lymphocytes / Cancer Vaccines / Carcinoma, Pancreatic Ductal / Antigens, Neoplasm Limits: Humans Language: En Journal: Nature Year: 2023 Type: Article Affiliation country: United States