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Interleukin-6 Drives Mitochondrial Dysregulation and Accelerates Physical Decline: Insights From an Inducible Humanized IL-6 Knock-In Mouse Model.
Nidadavolu, Lolita S; Cosarderelioglu, Caglar; Merino Gomez, Alessandra; Wu, Yuqiong; Bopp, Taylor; Zhang, Cissy; Nguyen, Tu; Marx-Rattner, Ruth; Yang, Huanle; Antonescu, Corina; Florea, Liliana; Talbot, Conover C; Smith, Barbara; Foster, D Brian; Fairman, Jennifer E; Yenokyan, Gayane; Chung, Tae; Le, Anne; Walston, Jeremy D; Abadir, Peter M.
Affiliation
  • Nidadavolu LS; Division of Geriatrics and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Cosarderelioglu C; Division of Geriatrics and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Merino Gomez A; Division of Geriatrics and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Wu Y; Division of Geriatrics and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Bopp T; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Zhang C; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Nguyen T; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Marx-Rattner R; Division of Geriatrics and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Yang H; Division of Geriatrics and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Antonescu C; Department of Genetic Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Florea L; Department of Genetic Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Talbot CC; Institute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Smith B; Department of Cell Biology, Imaging Facility, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Foster DB; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Fairman JE; Division of Cellular and Molecular Medicine, Department of Art as Applied to Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Yenokyan G; Johns Hopkins Biostatistics Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Chung T; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Le A; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Walston JD; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Abadir PM; Division of Geriatrics and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Gerontol A Biol Sci Med Sci ; 78(10): 1740-1752, 2023 10 09.
Article in En | MEDLINE | ID: mdl-37310873
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Full text: 1 Database: MEDLINE Main subject: Interleukin-6 / Frailty Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Gerontol A Biol Sci Med Sci Journal subject: GERIATRIA Year: 2023 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Interleukin-6 / Frailty Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Gerontol A Biol Sci Med Sci Journal subject: GERIATRIA Year: 2023 Type: Article Affiliation country: United States