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Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility.
Schoenthaler, Martin; Waltl, Lorenz; Hasenoehrl, Thomas; Seher, David; Lutz, Anna; Aulinger, Lucia; Temml, Veronika; König, Stefanie; Siller, Anita; Braun, Doris Elfriede; Garscha, Ulrike; Werz, Oliver; Schuster, Daniela; Schennach, Harald; Koeberle, Andreas; Matuszczak, Barbara.
Affiliation
  • Schoenthaler M; Institute of Pharmacy, Department of Pharmaceutical Chemistry, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
  • Waltl L; Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Mitterweg 24, A-6020 Innsbruck, Austria.
  • Hasenoehrl T; Institute of Pharmacy, Department of Pharmaceutical Chemistry, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
  • Seher D; Institute of Pharmacy, Department of Pharmaceutical Chemistry, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
  • Lutz A; Institute of Pharmacy, Department of Pharmaceutical Chemistry, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria; Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Mitterweg 24, A-6020 Innsbruc
  • Aulinger L; Institute of Pharmacy, Department of Pharmaceutical Chemistry, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria; Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Mitterweg 24, A-6020 Innsbruc
  • Temml V; Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Paracelsus Medical University Salzburg, Strubergasse 21, A-5020 Salzburg, Austria.
  • König S; Institute of Pharmacy, Department of Pharmaceutical/Medicinal Chemistry, University of Greifswald, Friedrich-Ludwig-Jahn-Straße 17, D-17489 Greifswald, Germany.
  • Siller A; Central Institute for Blood Transfusion and Immunology, Tirol Kliniken GmbH, Anichstraße 35, A-6020 Innsbruck, Austria.
  • Braun DE; Institute of Pharmacy, Department of Pharmaceutical Technology, Josef-Moeller-Haus, University of Innsbruck, Innrain 52c, A-6020 Innsbruck, Austria.
  • Garscha U; Institute of Pharmacy, Department of Pharmaceutical/Medicinal Chemistry, University of Greifswald, Friedrich-Ludwig-Jahn-Straße 17, D-17489 Greifswald, Germany.
  • Werz O; Department of Pharmaceutical/Medicinal Chemistry, Friedrich Schiller University Jena, Philosophenweg 14, D-07743 Jena, Germany.
  • Schuster D; Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Paracelsus Medical University Salzburg, Strubergasse 21, A-5020 Salzburg, Austria.
  • Schennach H; Central Institute for Blood Transfusion and Immunology, Tirol Kliniken GmbH, Anichstraße 35, A-6020 Innsbruck, Austria.
  • Koeberle A; Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Mitterweg 24, A-6020 Innsbruck, Austria. Electronic address: andreas.koeberle@uibk.ac.at.
  • Matuszczak B; Institute of Pharmacy, Department of Pharmaceutical Chemistry, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria. Electronic address: barbara.matuszczak@uibk.ac.at.
Bioorg Chem ; 139: 106685, 2023 10.
Article in En | MEDLINE | ID: mdl-37418786
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Full text: 1 Database: MEDLINE Main subject: Lipoxygenase Inhibitors / 5-Lipoxygenase-Activating Protein Inhibitors Limits: Humans Language: En Journal: Bioorg Chem Year: 2023 Type: Article Affiliation country: Austria
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Full text: 1 Database: MEDLINE Main subject: Lipoxygenase Inhibitors / 5-Lipoxygenase-Activating Protein Inhibitors Limits: Humans Language: En Journal: Bioorg Chem Year: 2023 Type: Article Affiliation country: Austria