The DoDo experience: an alternative antiretroviral 2-drug regimen of doravirine and dolutegravir.
Infection
; 51(6): 1823-1829, 2023 Dec.
Article
in En
| MEDLINE
| ID: mdl-37526898
ABSTRACT
BACKGROUND:
Currently available antiretroviral 2-drug regimen (2DR) fixed dose combinations may not be suitable for specific situations including the presence of resistance associated mutations (RAM) or drug - drug interactions (DDI). The data on the use of the non-nucleoside reverse transcriptase inhibitor doravirine (DOR) and the integrase inhibitor dolutegravir (DTG) as an alternative 2DR remain scarce.METHODS:
People living with HIV with DOR + DTG as a 2DR are being followed in a prospective observational study.RESULTS:
This analysis describes 85 participants with a median age of 57 years. Median CD4-nadir was 173/µl and a majority (66%) had a history of HIV-associated or AIDS-defining conditions. Antiretroviral history was mostly extensive, and documentation of RAM was frequent. The main reasons for choosing DOR + DTG were DDI (29%), tolerability (25%), and cardiovascular risk reduction (21%). Plasma viral load at switch was < 50 copies/ml in all but 3 instances, median CD4 count was 600/µl. DOR + DTG was later changed to another regimen in 10 participants after a median of 265 days, the other 75 participants have remained on DOR + DTG for a median of 947 days.CONCLUSION:
DOR + DTG as a 2DR proved to be a durable treatment option even in extensively pretreated individuals.Key words
Full text:
1
Database:
MEDLINE
Main subject:
HIV Infections
/
Acquired Immunodeficiency Syndrome
/
Anti-HIV Agents
Type of study:
Observational_studies
Limits:
Humans
/
Middle aged
Language:
En
Journal:
Infection
Year:
2023
Type:
Article
Affiliation country:
Germany