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First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MHV370, a Dual Inhibitor of Toll-Like Receptors 7 and 8, in Healthy Adults.
Shisha, Tamas; Posch, Maximilian G; Lehmann, Jeanette; Feifel, Roland; Junt, Tobias; Hawtin, Stuart; Schuemann, Jens; Avrameas, Alexandre; Danekula, Rambabu; Misiolek, Patrycja; Siegel, Richard; Gergely, Peter.
Affiliation
  • Shisha T; Novartis Pharma AG, Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland. tamas.shisha@novartis.com.
  • Posch MG; Charité Research Organisation GmbH, Berlin, Germany.
  • Lehmann J; Charité Research Organisation GmbH, Berlin, Germany.
  • Feifel R; Novartis Pharma AG, Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland.
  • Junt T; Novartis Pharma AG, Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland.
  • Hawtin S; Novartis Pharma AG, Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland.
  • Schuemann J; Novartis Pharma AG, Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland.
  • Avrameas A; Novartis Pharma AG, Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland.
  • Danekula R; Novartis Pharma AG, Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland.
  • Misiolek P; Novartis Pharma AG, Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland.
  • Siegel R; Novartis Pharma AG, Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland.
  • Gergely P; Novartis Pharma AG, Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland.
Eur J Drug Metab Pharmacokinet ; 48(5): 553-566, 2023 Sep.
Article in En | MEDLINE | ID: mdl-37532923
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Full text: 1 Database: MEDLINE Main subject: Toll-Like Receptor 7 / Toll-Like Receptor 8 Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Animals / Humans Language: En Journal: Eur J Drug Metab Pharmacokinet Year: 2023 Type: Article Affiliation country: Switzerland
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Full text: 1 Database: MEDLINE Main subject: Toll-Like Receptor 7 / Toll-Like Receptor 8 Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Animals / Humans Language: En Journal: Eur J Drug Metab Pharmacokinet Year: 2023 Type: Article Affiliation country: Switzerland