TfOH-Catalyzed Cascade Reaction: Metal-Free Access to 3,3-Disubstituted Phthalides from o-Alkynylbenzoic Acids.
J Org Chem
; 88(18): 12924-12934, 2023 Sep 15.
Article
in En
| MEDLINE
| ID: mdl-37643422
ABSTRACT
A facile new method for the synthesis of 3,3-disubstituted phthalides is reported. A successive reaction process begins with the TfOH-catalyzed cyclization of o-alkynylbenzoic acids followed by an ortho-regioselective electrophilic alkylation of various electron-rich aromatic compounds or alkenes, which has been successfully developed. The corresponding regioselective products of 3-substituted phthalide were obtained in good to high yields.
Full text:
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Database:
MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2023
Type:
Article