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Telomere length and risk of cirrhosis, hepatocellular carcinoma, and cholangiocarcinoma in 63,272 individuals from the general population.
Gellert-Kristensen, Helene; Bojesen, Stig E; Tybjærg Hansen, Anne; Stender, Stefan.
Affiliation
  • Gellert-Kristensen H; Department of Clinical Biochemistry, Rigshospitalet, Denmark.
  • Bojesen SE; Copenhagen University Hospitals and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Tybjærg Hansen A; Copenhagen University Hospitals and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Stender S; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Denmark.
Hepatology ; 79(4): 857-868, 2024 Apr 01.
Article in En | MEDLINE | ID: mdl-37732945
BACKGROUND AND AIMS: Inherited short telomeres are associated with a risk of liver disease, whereas longer telomeres predispose to cancer. The association between telomere length and risk of HCC and cholangiocarcinoma remains unknown. APPROACH AND RESULTS: We measured leukocyte telomere length using multiplex PCR in 63,272 individuals from the Danish general population. Telomere length and plasma ALT concentration were not associated (ß = 4 ×10 -6 , p -value = 0.06) in a linear regression model, without any signs of a nonlinear relationship. We tested the association between telomere length and risk of cirrhosis, HCC, and cholangiocarcinoma using Cox regression. During a median follow-up of 11 years, 241, 76, and 112 individuals developed cirrhosis, HCC, and cholangiocarcinoma, respectively. Telomere length and risk of cirrhosis were inversely and linearly associated ( p -value = 0.004, p for nonlinearity = 0.27). Individuals with telomeres in the shortest vs. longest quartile had a 2.25-fold higher risk of cirrhosis. Telomere length and risk of HCC were nonlinearly associated ( p -value = 0.009, p -value for nonlinearity = 0.01). This relationship resembled an inverted J-shape, with the highest risk observed in individuals with short telomeres. Individuals with telomeres in the shortest versus longest quartile had a 2.29-fold higher risk of HCC. Telomere length was inversely and linearly associated with the risk of cholangiocarcinoma. Individuals with telomeres in the shortest versus longest quartile had a 1.86-fold higher risk of cholangiocarcinoma. CONCLUSIONS: Shorter telomere length is associated with a higher risk of cirrhosis, HCC, and cholangiocarcinoma.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Bile Duct Neoplasms / Cholangiocarcinoma / Carcinoma, Hepatocellular / Liver Neoplasms Type of study: Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: Hepatology Year: 2024 Type: Article Affiliation country: Denmark

Full text: 1 Database: MEDLINE Main subject: Bile Duct Neoplasms / Cholangiocarcinoma / Carcinoma, Hepatocellular / Liver Neoplasms Type of study: Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: Hepatology Year: 2024 Type: Article Affiliation country: Denmark