Genomics of Treatable Traits in Asthma.
Genes (Basel)
; 14(9)2023 09 20.
Article
in En
| MEDLINE
| ID: mdl-37761964
ABSTRACT
The astounding number of genetic variants revealed in the 15 years of genome-wide association studies of asthma has not kept pace with the goals of translational genomics. Moving asthma diagnosis from a nonspecific umbrella term to specific phenotypes/endotypes and related traits may provide insights into features that may be prevented or alleviated by therapeutical intervention. This review provides an overview of the different asthma endotypes and phenotypes and the genomic findings from asthma studies using patient stratification strategies and asthma-related traits. Asthma genomic research for treatable traits has uncovered novel and previously reported asthma loci, primarily through studies in Europeans. Novel genomic findings for asthma phenotypes and related traits may arise from multi-trait and specific phenotyping strategies in diverse populations.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Asthma
/
Genome-Wide Association Study
Limits:
Humans
Language:
En
Journal:
Genes (Basel)
Year:
2023
Type:
Article
Affiliation country:
Spain