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HYPERREFLECTIVE FOCI NOT SEEN AS HYPERPIGMENTARY ABNORMALITIES ON COLOR FUNDUS PHOTOGRAPHS IN AGE-RELATED MACULAR DEGENERATION.
Goh, Kai Lyn; Wintergerst, Maximilian W M; Abbott, Carla J; Hadoux, Xavier; Jannaud, Maxime; Kumar, Himeesh; Hodgson, Lauren A B; Guzman, Gabriela; Janzen, Simon; van Wijngaarden, Peter; Finger, Robert P; Guymer, Robyn H; Wu, Zhichao.
Affiliation
  • Goh KL; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Wintergerst MWM; Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Australia; and.
  • Abbott CJ; Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.
  • Hadoux X; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Jannaud M; Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Australia; and.
  • Kumar H; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Hodgson LAB; Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Australia; and.
  • Guzman G; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Janzen S; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • van Wijngaarden P; Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Australia; and.
  • Finger RP; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Guymer RH; Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.
  • Wu Z; Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.
Retina ; 44(2): 214-221, 2024 Feb 01.
Article in En | MEDLINE | ID: mdl-37831941
ABSTRACT

PURPOSE:

To investigate the prognostic value of quantifying optical coherence tomography (OCT)-defined hyperreflective foci (HRF) that do not correspond to hyperpigmentary abnormalities (HPAs) on color fundus photographs (CFPs)-HRF (OCT+/CFP-) -when considered in addition to HPA extent, for predicting late age-related macular degeneration development. This study sought to understand the impact of HRF (OCT+/CFP-) extent on visual sensitivity.

METHODS:

Two hundred eighty eyes from 140 participants with bilateral large drusen underwent imaging and microperimetry at baseline, and then 6-monthly for 3-years. The extent of HPAs on CFPs and HRF (OCT+/CFP-) on OCT was quantified at baseline. Predictive models for progression to late age-related macular degeneration, accounting for drusen volume and age, were developed using HPA extent, with and without HRF (OCT+/CFP-) extent. The association between HPA and HRF (OCT+/CFP-) extent with sector-based visual sensitivity was also evaluated.

RESULTS:

Incorporating HRF (OCT+/CFP-) extent did not improve the predictive performance for late age-related macular degeneration development ( P ≥ 0.32). Increasing HPA and HRF (OCT+/CFP-) extent in each sector were independently and significantly associated with reduced sector-based visual sensitivity ( P ≤ 0.004).

CONCLUSION:

The addition of HRF (OCT+/CFP-) extent to HPA extent did not improve the prediction of late age-related macular degeneration development. HRF (OCT+/CFP-) extent was also independently associated with local reductions in visual sensitivity, after accounting for HPAs.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Retinal Drusen / Macular Degeneration Limits: Humans Language: En Journal: Retina Year: 2024 Type: Article Affiliation country: Australia

Full text: 1 Database: MEDLINE Main subject: Retinal Drusen / Macular Degeneration Limits: Humans Language: En Journal: Retina Year: 2024 Type: Article Affiliation country: Australia