Parietal resting-state EEG alpha source connectivity is associated with subcortical white matter lesions in HIV-positive people.
Clin Neurophysiol
; 156: 19-27, 2023 12.
Article
in En
| MEDLINE
| ID: mdl-37844524
ABSTRACT
OBJECTIVE:
Parietal resting-state electroencephalographic (rsEEG) alpha (8-10 Hz) source connectivity is abnormal in HIV-positive persons. Here we tested whether this abnormality may be associated with subcortical white matter vascular lesions in the cerebral hemispheres.METHODS:
Clinical, rsEEG, and magnetic resonance imaging (MRI) datasets in 38 HIV-positive persons and clinical and rsEEG datasets in 13 healthy controls were analyzed. Radiologists visually evaluated the subcortical white matter hyperintensities from T2-weighted FLAIR MRIs (i.e., Fazekas scale). In parallel, neurophysiologists estimated the eLORETA rsEEG source lagged linear connectivity from parietal cortical regions of interest.RESULTS:
Compared to the HIV participants with no/negligible subcortical white matter hyperintensities, the HIV participants with mild/moderate subcortical white matter hyperintensities showed lower parietal interhemispheric rsEEG alpha lagged linear connectivity. This effect was also observed in HIV-positive persons with unimpaired cognition. This rsEEG marker allowed good discrimination (area under the receiver operating characteristic curve > 0.80) between the HIV-positive individuals with different amounts of subcortical white matter hyperintensities.CONCLUSIONS:
The parietal rsEEG alpha source connectivity is associated with subcortical white matter vascular lesions in HIV-positive persons, even without neurocognitive disorders.SIGNIFICANCE:
Those MRI-rsEEG markers may be used to screen HIV-positive persons at risk of neurocognitive disorders.Key words
Full text:
1
Database:
MEDLINE
Main subject:
HIV Infections
/
Alzheimer Disease
/
White Matter
Limits:
Humans
Language:
En
Journal:
Clin Neurophysiol
Journal subject:
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2023
Type:
Article