NUT carcinoma and thoracic SMARCA4-deficient undifferentiated tumour: facts and controversies.
Histopathology
; 84(1): 86-101, 2024 Jan.
Article
in En
| MEDLINE
| ID: mdl-37873676
ABSTRACT
NUT carcinoma and thoracic SMARCA4-deficient undifferentiated tumour are unique entities in the 5th edition of the World Health Organisation (WHO) Classification of Thoracic Tumours, whose definitions include molecular genetic abnormalities. These aggressive tumours require rapid work-ups on biopsies, but a broad list of differential diagnoses poses challenges for practising pathologists. This review provides an update on their key clinicopathological and molecular characteristics, as well as controversies regarding tumour classification and diagnostic strategy. Phenotypical assessment plays a substantial role in diagnosis because recurrent and predictable clinicopathological findings exist, including robust immunohistochemical phenotypes. Accurate diagnosis is crucial for appropriate management and a clearer understanding of the disease.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Thoracic Neoplasms
/
Carcinoma
Limits:
Humans
Language:
En
Journal:
Histopathology
Year:
2024
Type:
Article
Affiliation country:
Japan