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Structure, Function, and Regulation of the Junctophilin Family.
Hall, Duane D; Takeshima, Hiroshi; Song, Long-Sheng.
Affiliation
  • Hall DD; Department of Internal Medicine, Division of Cardiovascular Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA; email: duane-hall@uiowa.edu, long-sheng-song@uiowa.edu.
  • Takeshima H; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
  • Song LS; Department of Internal Medicine, Division of Cardiovascular Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA; email: duane-hall@uiowa.edu, long-sheng-song@uiowa.edu.
Annu Rev Physiol ; 86: 123-147, 2024 Feb 12.
Article in En | MEDLINE | ID: mdl-37931168
In both excitable and nonexcitable cells, diverse physiological processes are linked to different calcium microdomains within nanoscale junctions that form between the plasma membrane and endo-sarcoplasmic reticula. It is now appreciated that the junctophilin protein family is responsible for establishing, maintaining, and modulating the structure and function of these junctions. We review foundational findings from more than two decades of research that have uncovered how junctophilin-organized ultrastructural domains regulate evolutionarily conserved biological processes. We discuss what is known about the junctophilin family of proteins. Our goal is to summarize the current knowledge of junctophilin domain structure, function, and regulation and to highlight emerging avenues of research that help our understanding of the transcriptional, translational, and post-translational regulation of this gene family and its roles in health and during disease.
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Full text: 1 Database: MEDLINE Main subject: Sarcoplasmic Reticulum / Membrane Proteins Limits: Humans Language: En Journal: Annu Rev Physiol Year: 2024 Type: Article

Full text: 1 Database: MEDLINE Main subject: Sarcoplasmic Reticulum / Membrane Proteins Limits: Humans Language: En Journal: Annu Rev Physiol Year: 2024 Type: Article