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Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality.
Lin, Peter; Lourenco, Corey; Cruickshank, Jennifer; Palomero, Luis; van Leeuwen, Jenna E; Tong, Amy H Y; Chan, Katherine; El Ghamrasni, Samah; Pujana, Miquel Angel; Cescon, David W; Moffat, Jason; Penn, Linda Z.
Affiliation
  • Lin P; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
  • Lourenco C; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • Cruickshank J; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
  • Palomero L; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • van Leeuwen JE; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • Tong AHY; ProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.
  • Chan K; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
  • El Ghamrasni S; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • Pujana MA; Donnelly Centre, University of Toronto, Toronto, Canada.
  • Cescon DW; Donnelly Centre, University of Toronto, Toronto, Canada.
  • Moffat J; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • Penn LZ; ProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.
Cancer Res ; 83(24): 4015-4029, 2023 12 15.
Article in En | MEDLINE | ID: mdl-37987734
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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / R-Loop Structures Limits: Female / Humans Language: En Journal: Cancer Res Year: 2023 Type: Article Affiliation country: Canada
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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / R-Loop Structures Limits: Female / Humans Language: En Journal: Cancer Res Year: 2023 Type: Article Affiliation country: Canada