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ARFID Genes and Environment (ARFID-GEN): study protocol.
Bulik, Cynthia M; Micali, Nadia; MacDermod, Casey M; Qi, Baiyu; Munn-Chernoff, Melissa A; Thornton, Laura M; White, Jennifer; Dinkler, Lisa; Pisetsky, Emily M; Johnson, Jessica; Devine, Katelin R; Ortiz, Shelby N; Silverman, Ava E; Berthold, Natasha; Dumain, Alexis; Guintivano, Jerry; Halvorsen, Matthew; Crowley, James J.
Affiliation
  • Bulik CM; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. cynthia_bulik@med.unc.edu.
  • Micali N; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden. cynthia_bulik@med.unc.edu.
  • MacDermod CM; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, US. cynthia_bulik@med.unc.edu.
  • Qi B; Center for Eating and Feeding Disorders Research, Psychiatric Center Ballerup, Mental Health Services of the Capital Region of Denmark, Ballerup, Denmark.
  • Munn-Chernoff MA; Institute of Biological Psychiatry, Psykiatrisk Center Sct. Hans, Boserupvej 2, 4000, Roskilde, Denmark.
  • Thornton LM; Great Ormond Street Hospital Institute of Child Health, University College London, London, UK.
  • White J; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Dinkler L; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA.
  • Pisetsky EM; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Johnson J; Texas Tech University, Lubbock, TX, 79409, USA.
  • Devine KR; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Ortiz SN; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Silverman AE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden.
  • Berthold N; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Dumain A; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Guintivano J; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Halvorsen M; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Crowley JJ; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
BMC Psychiatry ; 23(1): 863, 2023 11 21.
Article in En | MEDLINE | ID: mdl-37990202
ABSTRACT

BACKGROUND:

The Avoidant Restrictive Food Intake Disorder - Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults.

METHODS:

A total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18 +) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted.

DISCUSSION:

ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver "actionable" findings that can be transformed into clinically meaningful insights. TRIAL REGISTRATION ARFID-GEN is a registered clinical trial clinicaltrials.gov NCT05605067.
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Full text: 1 Database: MEDLINE Main subject: Feeding and Eating Disorders / Avoidant Restrictive Food Intake Disorder Limits: Adult / Child / Humans Language: En Journal: BMC Psychiatry Journal subject: PSIQUIATRIA Year: 2023 Type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Feeding and Eating Disorders / Avoidant Restrictive Food Intake Disorder Limits: Adult / Child / Humans Language: En Journal: BMC Psychiatry Journal subject: PSIQUIATRIA Year: 2023 Type: Article Affiliation country: United States