Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges.
Histopathology
; 84(1): 216-237, 2024 Jan.
Article
in En
| MEDLINE
| ID: mdl-37994540
ABSTRACT
This article will review current aspects of the histopathological, immunohistochemical and molecular analysis of primary mediastinal germ cell tumours (PMGCTs) as well as their aetiological, epidemiological, clinical and therapeutic features. PMGCTs represent an important differential diagnosis in the spectrum of mediastinal tumours, and their diagnosis is usually made on small tissue samples from core needle biopsies in combination with diagnostic imaging and serum tumour markers. As in lymphomas, a small biopsy is often the only viable tumour sample available from these patients, as they receive chemotherapy prior to eventual surgical resection. Pathologists therefore need to apply an efficient combination of immunohistochemical markers to confirm the diagnosis of a PMGCT and to exclude morphological mimics.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Neoplasms, Germ Cell and Embryonal
/
Lymphoma
/
Mediastinal Neoplasms
Limits:
Humans
Language:
En
Journal:
Histopathology
Year:
2024
Type:
Article
Affiliation country:
Germany