A case of hepatitis-associated aplastic anaemia following living-donor liver transplantation for fulminant hepatitis showing loss of heterozygosity in the 6p chromosome in the affected liver.
Br J Haematol
; 204(2): 623-627, 2024 02.
Article
in En
| MEDLINE
| ID: mdl-38011365
ABSTRACT
The mechanisms underlying hepatitis-associated aplastic anaemia (HAAA) that occurs several weeks after the development of acute hepatitis are unknown. A 20-year-old male developed HAAA following living-donor liver transplantation for fulminant hepatitis. The patient's leucocytes lacked HLA-class I due to loss of heterozygosity in the short arm of chromosome 6p (6pLOH). Interestingly, the patient's liver cells resected during the transplantation also exhibited 6pLOH that affected the same HLA haplotype as the leucocytes, suggesting that CD8+ T cells recognizing antigens presented by specific HLA molecules on liver cells may have attacked the haematopoietic stem cells of the patient, leading to the HAAA development.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Liver Transplantation
/
Massive Hepatic Necrosis
/
Hepatitis
/
Hepatitis A
/
Anemia, Aplastic
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Br J Haematol
Year:
2024
Type:
Article
Affiliation country:
Japan