Transcriptome analysis revealed that PME-1 suppresses inflammatory signaling, activates PI3K/Akt signaling, and promotes epithelial-mesenchymal transition.
Biochem Biophys Res Commun
; 692: 149148, 2024 Jan 15.
Article
in En
| MEDLINE
| ID: mdl-38043157
ABSTRACT
Protein phosphatase 2A (PP2A) is an essential serine/threonine protein phosphatase that belongs to the type2A protein phosphatase family with PP4 and PP6. PP2A functions as a trimeric holoenzyme, and the composition of the trimer is regulated by the methyl-esterification (methylation) of PP2A. Demethylation of PP2A is catalyzed by protein phosphatase methyl-esterase-1 (PME-1). Despite the physiological and pathophysiological importance of PME-1, the impact of changes in PME-1 expression on the transcriptome has not been reported. This study provides transcriptome data to gain a comprehensive understanding of the effects of PME-1 knockout on intracellular signaling of mouse embryonic fibroblasts. Our data showed that PME-1 suppresses inflammatory signaling, activates PI3K/Akt signaling, and promotes epithelial-mesenchymal transition.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Phosphatidylinositol 3-Kinases
/
Proto-Oncogene Proteins c-akt
Limits:
Animals
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2024
Type:
Article
Affiliation country:
Japan