Novel combinatorial therapy of oncolytic adenovirus AdV5/3-D24-ICOSL-CD40L with anti PD-1 exhibits enhanced anti-cancer efficacy through promotion of intratumoral T-cell infiltration and modulation of tumour microenvironment in mesothelioma mouse model.

Garofalo, Mariangela; Wieczorek, Magdalena; Anders, Ines; Staniszewska, Monika; Lazniewski, Michal; Prygiel, Marta; Zasada, Aleksandra Anna; Szczepinska, Teresa; Plewczynski, Dariusz; Salmaso, Stefano; Caliceti, Paolo; Cerullo, Vincenzo; Alemany, Ramon; Rinner, Beate; Pancer, Katarzyna; Kuryk, Lukasz

Garofalo, Mariangela; Wieczorek, Magdalena; Anders, Ines; Staniszewska, Monika; Lazniewski, Michal; Prygiel, Marta; Zasada, Aleksandra Anna; Szczepinska, Teresa; Plewczynski, Dariusz; Salmaso, Stefano; Caliceti, Paolo; Cerullo, Vincenzo; Alemany, Ramon; Rinner, Beate; Pancer, Katarzyna; Kuryk, Lukasz.

Affiliation

Garofalo M; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Wieczorek M; Department of Virology, National Institute of Public Health, National Institute of Hygiene (NIH) - National Research Institute, Warsaw, Poland.
Anders I; Division of Biomedical Research, Medical University of Graz, Graz, Austria.
Staniszewska M; Centre for Advanced Materials and Technologies, Warsaw University of Technology, Warsaw, Poland.
Lazniewski M; Centre for Advanced Materials and Technologies, Warsaw University of Technology, Warsaw, Poland.
Prygiel M; Department of Bacteriology and Biocontamination Control, National Institute of Public Health, National Institute of Hygiene (NIH) - National Research Institute, Warsaw, Poland.
Zasada AA; Departament of Sera and Vaccines Evaluation, National Institute of Public Health, National Institute of Hygiene (NIH) - National Research Institute, Warsaw, Poland.
Szczepinska T; Departament of Sera and Vaccines Evaluation, National Institute of Public Health, National Institute of Hygiene (NIH) - National Research Institute, Warsaw, Poland.
Plewczynski D; Centre for Advanced Materials and Technologies, Warsaw University of Technology, Warsaw, Poland.
Salmaso S; Laboratory of Bioinformatics and Computational Genomics, Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland.
Caliceti P; Laboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Cerullo V; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Alemany R; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Rinner B; Drug Research Program (DRP), ImmunoViroTherapy Lab (IVT), Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Pancer K; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Kuryk L; Translational Immunology Program (TRIMM), Faculty of Medicine Helsinki University, University of Helsinki, Helsinki, Finland.