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5-exo-Selective asymmetric bromolactonization of stilbenecarboxylic acids catalyzed by phenol-bearing chiral thiourea.
Sugano, Masayuki; Inokuma, Tsubasa; Yamaoka, Yousuke; Yamada, Ken-Ichi.
Affiliation
  • Sugano M; Graduate School of Pharmaceutical Sciences, Tokushima University, Shomachi, Tokushima 770-8505, Japan. yamak@tokushima-u.ac.jp.
  • Inokuma T; Graduate School of Pharmaceutical Sciences, Tokushima University, Shomachi, Tokushima 770-8505, Japan. yamak@tokushima-u.ac.jp.
  • Yamaoka Y; Research Cluster on "Key Material Development, " Tokushima University, Shomachi, Tokushima 770-8505, Japan.
  • Yamada KI; Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
Org Biomol Chem ; 22(9): 1765-1769, 2024 Feb 28.
Article in En | MEDLINE | ID: mdl-38099597
ABSTRACT
We developed a novel thiourea Lewis-base catalyst with phenol moieties for the enantioselective 5-exo-bromolactonization of stilbenecarboxylic acids to afford chiral 3-substituted phthalides. The phenol moieties are crucial for the enantio- and regio-selectivity.
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Full text: 1 Database: MEDLINE Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Type: Article Affiliation country: Japan
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Full text: 1 Database: MEDLINE Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Type: Article Affiliation country: Japan