Viscoelastic coagulation monitoring for tranexamic acid: personalised antifibrinolytic dosing?
Br J Anaesth
; 132(2): 227-229, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38123441
ABSTRACT
Ex vivo viscoelastic testing can be used to assess the concentration responses to tranexamic acid in blood samples obtained from pregnant women across the three trimesters and in non-pregnant controls. Minor variations in fibrinolysis across pregnancy suggest a target tranexamic acid blood concentration of 12.5 mg L-1 for complete inhibition of fibrinolysis. Although the data support the potential utility of viscoelastic testing using the ClotPro® TPA test in maintaining therapeutic tranexamic acid concentrations during postpartum haemorrhage, it might obscure potentially crucial endogenous fibrinolysis inhibitor interactions essential to the microcirculation.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Tranexamic Acid
/
Blood Coagulation
/
Antifibrinolytic Agents
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Br J Anaesth
Year:
2024
Type:
Article