Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury.
Cell Rep
; 43(1): 113591, 2024 01 23.
Article
in En
| MEDLINE
| ID: mdl-38153838
ABSTRACT
While fecal microbiota transplantation (FMT) shows promise in treating human diseases, oral capsule FMT is more accepted and accessible to patients. However, microbe selection in the upper gastrointestinal tract (UGIT) through oral administration remains unclear. Here, we demonstrate that short-term oral fecal gavage (OFG) alleviates acetaminophen-induced acute liver injury (AILI) in mice, regardless of the divergent effects of commensal gut microbes. Pasteurized fecal gavage yields similar therapeutic effects. OFG enriches gut Lachnospiraceae and butyrate compared to donor feces. Butyrate mitigates AILI-induced ferroptosis via AMPK-ULK1-p62 signaling to simultaneously induce mitophagy and Nrf2 antioxidant responses. Combined N-acetylcysteine and butyrate administration significantly improves AILI mouse survival rates. These observations indicate the significance of the UGIT in modulating the implanted fecal microbes through oral administration and its potential biological and clinical impacts. Our findings also highlight a possible strategy for applying microbial metabolites to treat acute liver injury.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Butyrates
/
Fecal Microbiota Transplantation
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell Rep
Year:
2024
Type:
Article
Affiliation country:
Taiwan