Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling.
Trends Biochem Sci
; 49(2): 156-168, 2024 02.
Article
in En
| MEDLINE
| ID: mdl-38158273
ABSTRACT
Membrane adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. As effector proteins of G protein-coupled receptors and other signaling pathways, ACs receive and amplify signals from the cell surface, translating them into biochemical reactions in the intracellular space and integrating different signaling pathways. Despite their importance in signal transduction and physiology, our knowledge about the structure, function, regulation, and molecular interactions of ACs remains relatively scarce. In this review, we summarize recent advances in our understanding of these membrane enzymes.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Signal Transduction
/
Adenylyl Cyclases
Language:
En
Journal:
Trends Biochem Sci
Year:
2024
Type:
Article