Protein kinase CK2: An emerging regulator of cellular metabolism.
Biofactors
; 50(4): 624-633, 2024.
Article
in En
| MEDLINE
| ID: mdl-38158592
ABSTRACT
The protein kinase casein kinase 2 (CK2) exerts its influence on the metabolism of three major cellular substances by phosphorylating essential protein molecules involved in various cellular metabolic pathways. These substances include hormones, especially insulin, rate-limiting enzymes, transcription factors of key genes, and cytokines. This regulatory role of CK2 is closely tied to important cellular processes such as cell proliferation and apoptosis. Additionally, tumor cells undergo metabolic reprogramming characterized by aerobic glycolysis, accelerated lipid ß-oxidation, and abnormally active glutamine metabolism. In this context, CK2, which is overexpressed in various tumors, also plays a pivotal role. Hence, this review aims to summarize the regulatory mechanisms of CK2 in diverse metabolic pathways and tumor development, providing novel insights for the diagnosis, treatment, and prognosis of metabolism-related diseases and cancers.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Casein Kinase II
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Biofactors
Journal subject:
BIOQUIMICA
Year:
2024
Type:
Article
Affiliation country:
China