[Use of a controlled attenuation parameter for the diagnosis of non-alcoholic fatty liver disease].
Ter Arkh
; 95(8): 641-647, 2023 Oct 11.
Article
in Ru
| MEDLINE
| ID: mdl-38158897
ABSTRACT
AIM:
To evaluate the efficacy of vibration-controlled transient elastography (VCTE) with a controlled attenuation parameter (CAP) in a population of patients with non-alcoholic fatty liver disease (NAFLD)and to compare to US and different non-invasive indices. MATERIALS ANDMETHODS:
Single center NAFLD patients' database of 2021-2023 years was retrospectively analysed. Data of VCTE evaluation with CAP (FibroScan 530® and FibroScan 630 Expert®) as well as liver US examination results and values of HSI, FLI, BAAT and NAFLD-LFS were extracted. AUROCs for all methods used were constructed and sensitivity and specificity analysis was performed.RESULTS:
The data of 1081 patients were available for analysis (385 with steatosis, 274 with NASH, 422 without NAFLD as a control). Ultrasound examination in the diagnosis of liver steatosis compared to VCTE with CAP showed sensitivity and specificity of 94.6 and 63.7%, respectively. Diagnosis of liver steatosis using indices and scales showed sensitivity and specificity of HSI 97.9 and 60.1% (AUROC 0.90), FLI 92.5 and 85.3% (AUROC 0.93), BAAT 76.6 and 73.5% (AUROC 0.82), NAFLD-LFS 56.7 and 81.8% (AUROC 0.85).CONCLUSION:
The sensitivity of the US of the liver was consistent with previous studies, but the specificity was low. The HSI index had the best indicators of sensitivity and specificity in relation to the diagnosis of liver steatosis. Combination of liver US and HSI can be used in screening of liver steatosis, however, for the complete diagnosis better tools which can simultaneously evaluate liver steatosis and fibrosis should be used.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Elasticity Imaging Techniques
/
Non-alcoholic Fatty Liver Disease
Limits:
Humans
Language:
Ru
Journal:
Ter Arkh
Year:
2023
Type:
Article